Illness is the natural phenomenon and no human being in the universe is safe from diseases. The Quran and Prophetic traditions gives detailed guidance about this natural factor. Islam is pragmatic religion in its core teachings and deals with all human issues in a realistic manner. The juristic commandments regarding cure and medication are the evidence of practicality of Islamic rulings. This article provides sufficient information about technical definition of disease, admissibility of medication in Shariah, attributes of a druggist in religious perspective, permissibility of making medicines with lawful things and juristic differences upon producing medicine from prohibited materials like wine and narcotics. The article has been written in analytical mode and opinions of ancient jurists have been quoted to authenticate debate.