Employee’s Work Engagement has become an important concern for organizations as it accomplishes long run viable competitive advantages. The aim of current study was to examine the linkage amongIslamic spirituality andIslamic leadership responsibility, with the employee work engagement. Using a purposive sampling technique, the survey data utilized for this empirical research was drawn from 380 respondents from Small and Micro level organizations in Lahore. Using SPSS software and employing regression analysis, the study tests several hypotheses that components of Islamic spirituality and Islamic leadership responsibility will exert statistically significant impacts on employee work engagement. The study found support for both main hypotheses. The model can explain over 20 % of the variance in employee work engagement. This is primarily backed by Sadakah and integrity indicators of Islamic leadership responsibility.